Tamoxifen for ovulation induction

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  1. choupa New Member

    Tamoxifen for ovulation induction


    © Bioline International, 1989 - 2019, Site last up-dated on 21-Feb-2019. Background: Being a selective estrogen receptor inhibitor (SERM) tamoxifen may be used an alternative to clomiphene citrate for ovulation induction in women with anovulatory infertility. Comparison of tamoxifen and clomiphene citrate for ovulation induction: a meta-analysis. This study was conducted to evaluate the safety and efficacy of tamoxifen as compared to clomiphene citrate in women with primary or secondary anovulatory infertility due to Polycystic Ovarian Syndrome (PCOS). Methods: One hundred women suffering from anovulatory infertility and attending the infertility clinic and were recruited for the study. Williamson JG and Ellis JD The induction of ovulation by tamoxifen. Patients were randomized to receive either clomiphene citrate (100-150 mg) or tamoxifen treatment (40-80 mg). Kettal LM, Roseff SJ, Berga S et al: Hypothalamic-pituitary-ovarian response to clomiphene citrate women with polycystic ovary syndrome. Brown J, Farquhar C, Beck J, Boothroyd C, Proctor M, Hughes E. Eden JA, Place J, Carter GD, Jones J, Alaghband-Zadeh, Pawson ME. Characteristics relating to ovarian risk: Collaborative analysis of 12 US case-control studies. The ovulation was monitored from day 5 to day 9 of menstrual cycle followed up by transvaginal ultrasound from day 11 every alternate day for 10 days. Results: The baseline characteristics of mean age, weight, proportion of patients with primary and secondary infertility and mean duration of infertility were comparable between both the study groups. Clark JH, Markaverich BM: The agonistic-antagonistic properties of clomiphene: A review. Oral anti-estrogen and medical adjuncts for subfertility associated with anovulation. The effect of clomiphene citrate on follicular phase increase in endometrial thickness and uterine volume. Out of 50 patients who received clomiphene citrate, 37 showed successful ovulation (ovulation rate of 64%) and 16 patients conceived (pregnancy rate of 32%). In tamoxifen group 41 women showed successful ovulation (ovulation rate of 82%) and 18 women conceived (pregnancy rate of 36%).

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    Apr 21, 2005. Abstract. BACKGROUND Both selective estrogen receptor modulators, tamoxifen and clomiphene have been used for ovulation induction for. Clomiphene Citrate Versus Tamoxifen for Ovulation Induction in PCOs The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U. S. Federal Government. Tamoxifen for ovulation induction in infertile PCOS women who did not conceive with 3 or more cycles of clomiphene citrate A prospective.

    The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Group (B): 300 participants will receive Tamoxifen oral tablets and placebo of Clomiphene oral tablets. Listing a study does not mean it has been evaluated by the U. Participants with abnormal menstrual history will receive two tablets of norethisterone 5mg tab (Steronate nor ®, hi pharm/Egypt) every12 hours for 5 days to withdraw period before starting the procedure. Participants fulfilling inclusion and exclusion criteria will be divided into two groups, each group containing 300 participants; Group (A): 300 participants will receive Clomiphene citrate oral tablets and placebo of Tamoxifen oral tablets. Then; Group (A): Women will receive one tablet of clomiphene citrate oral tablets 50 mg (Clomid®, aventis/Egypt) twice daily 12 hours apart (total dose 100 mg daily), and one tablet of placebo of tamoxifen oral tablets twice daily 12 hours apart from the 3rd day of the menses for 5 days, for only one menstrual cycle. Group (B): Women will receive one tablet of tamoxifen oral tablets 10 mg (Tamoxifen®, amriya/Egypt) twice daily 12 hours apart (total dose 20 mg daily), and one tablet of placebo of clomiphene citrate twice daily 12 hours apart from 3rd day of the menses for 5 days, for only one menstrual cycle. Women will receive one tablet of clomiphene citrate oral tablets 50 mg (Clomid®, aventis/Egypt) twice daily 12 hours apart (total dose 100 mg daily), and one tablet of placebo of tamoxifen oral tablets twice daily 12 hours apart from the 3rd day of the menses for 5 days, for only one menstrual cycle. Women will receive one tablet of clomiphene citrate oral tablets 50 mg (Clomid®, aventis/Egypt) twice daily 12 hours apart (total dose 100 mg daily) from the 3rd day of the menses for 5 days, for only one menstrual cycle. BACKGROUND: Both selective estrogen receptor modulators, tamoxifen and clomiphene have been used for ovulation induction for patients with anovulatory infertility. This meta-analysis sought to compare the effectiveness of tamoxifen to clomiphene for the induction of ovulation and achievement of pregnancy. METHODS: We searched MEDLINE, BIOSIS, Pre MEDLINE, CINAHL, International Pharmaceutical Abstracts, DDSR, ACP Journal Club, DARE and CCTR, along with reference lists and national experts. Inclusion criteria were prospective clinical trials, which compared tamoxifen and clomiphene for ovulation induction in infertile couples with isolated anovulatory infertility. Main outcome measures were ovulation rate and clinical pregnancy rate. Pooled odds ratios were obtained using random effects meta-analysis. After pooling all the trials, the use of tamoxifen or clomiphene citrate resulted in similar ovulation rates [odds ratio (OR) 0.755, 95% confidence interval (CI) 0.513–1.111]. There was no benefit of tamoxifen over clomiphene citrate in achievement of pregnancy per cycle (OR 1.056, 95% CI 0.583–1.912) or per ovulatory cycle (OR 1.162, 95% CI 0.632–2.134).

    Tamoxifen for ovulation induction

    Tamoxifen - Ovulation Induction -, Clomiphene Citrate Versus Tamoxifen for Ovulation Induction.

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  7. Jun 24, 2015. Official Title Clomiphene Citrate Versus Tamoxifen for Induction of Ovulation in Women With Polycystic Ovary Syndrome Randomized.

    • Clomiphene Citrate Versus Tamoxifen for Ovulation Induction in PCOs..
    • Tamoxifen for ovulation induction in infertile PCOS women who did..
    • Comparison of tamoxifen and clomiphene citrate for ovulation..

    Summary. A new anti-oestrogen, tamoxifen, has been synthesized and is available for clinical trials. Its value in the treatment of anovulatory infertility has been. Official Title Clomiphene Citrate Versus Tamoxifen for Induction of Ovulation in Women With Polycystic Ovary Syndrome Randomized. Either clomiphene citrate or Tamoxifen had been suggested as the first line drug for ovulation induction in anovulatory women with PCOS 14. But, are both.

     
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