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The first day I felt pretty bad mostly I think because the drainage was suppressing my appetite and making me feel nauseous. It starts out as allergy symptoms, gets into the sinuses a bit, but ends up settling in my chest where I end up with a tender sternum, horse voice, although not able to break anything loose For the past 3 yeasrs tehy've started me out on a z-pack and I've ended up on prednisone.......and what is going on? I went to the doctor on Sunday and he said I had an infection and prescribed a Z-pack and prednisone. (I have lots of sinus infections, have had surgery on my sinuses, etc.) Doc gave me a z-pack and prednisone. Suggested I try Claritin or zyrtec to see if allergies are triggering all of this. Prednisone is a multi-purpose medication that can be used to repair the degrees of corticosteroids, and also to deal with a lot of various other problems. 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