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    Panosteitis is an idiopathic bone disease of young dogs, mostly affecting large or giant breeds. Investigators of the University of Bern, Switzerland, developed a plausible, empirically based hypothesis governing its pathogenesis. Extensive clinical observations suggest a close relationship between the incidence of this disease and the commercialization of various protein-rich, high-caloric dog foods. The theory of an ``osseous compartment syndrome`` provides a hypothetical pathogenesis, which corroborates this finding. An excessive accumulation of protein causes intraosseous edema due to its osmotic effects. Because bone is a rigid compartment, this leads to an increase in intramedullary pressure and compression of blood vessels. Subsequent osseous ischemia leads to a deficient metabolic state (decreased oxygenation, inadequate influx of nutritive substances, local acidosis, decreased removal of metabolites, disruption of local biochemical processes, etc.), and a vicious circle is created due to the resulting local inflammation. New hypothesis concerning pathogenesis of canine panosteitis Update on managing inflammatory bowel disease and intestinal. Prednisolone for Dogs and Cats Joint Pain Medication - 1800PetMeds
     
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