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  1. Giller Well-Known Member

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    The antiemetic domperidone’s reclassification shows the importance of pharmacovigilance, but the loss of such a useful over-the-counter medicine ought to have been better communicated to community pharmacies. On 3 September 2014, community pharmacists were given 48 hours to remove over-the-counter (OTC) domperidone products from their shelves over concerns about cardiac safety. The UK’s Medicines and Healthcare products Regulatory Agency had stripped the product of its status as a pharmacy medicine and the drug is now only available with a prescription. The injectable form of domperidone was withdrawn in 1985 because of cardiac side effects. But the oral form had long been considered to be well tolerated with minimal toxicity — which is why it was switched from prescription to pharmacy medicine in 1998 for the relief of post-prandial symptoms of fullness, nausea, bloating and belching, occasionally accompanied by epigastric discomfort and heartburn. The 10mg oral domperidone product had its OTC licence extended in 2010 to include the relief of nausea and vomiting lasting less than 48 hours. In consulting on the licence extension, the MHRA acknowledged that there are few treatments available for purchase in pharmacies to manage nausea and vomiting, leaving pharmacists frequently having to refer patients to their doctor. They work by easing the passing of food through the digestive system. This helps to treat both short term feelings of sickness, and other cases lasting for up to two weeks. In addition to this, it can help to reduce heartburn and trapped wind. Nausea is a condition where the body’s vomiting reflex is heightened by internal or external stimulus, resulting in the need to be sick. This stimulus sends messages to the vomiting centre in the brain, via the CTZ, or chemoreceptor trigger zone, telling the body that it needs to expel vomit. This then causes the spasms in the stomach which cause sickness. The stimulus can be one of any number of factors, with examples being those chemicals released during a migraine, conflicting signals brought on by opposing sensory information (such as in travel sickness), or the presence of an irritant in the stomach.

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    Though I have always thought of myself as a writer more than a teacher, I somehow found myself in teaching situations over the years, and I’ve always enjoyed the challenge. four years later I spent one semester as a substitute teacher at my former high school in Jericho, Long Island. It started with the Peace Corps, when I graduated from UCLA and wound up being asked to teach at the Ghana Institute of Journalism in West Africa. When someone I knew became the director of Antioch College/L. he asked if I would join him as an assistant director and I soon found myself developing a Masters in Professional Writing program, which I directed for four years. When my first daughter was born, I decided to stop teaching and just write, which I did for 20 years, until I was asked by the Chairman of the English Department at UCLA if I would teach what I had learned as a freelance writer. Over the next 10 years I taught four seminars: The Art of the Interview, The Literature of Journalism, Articles to Film, and Autobiography and Memoir Writing. During this time I was occasionally asked to lecture at different universities, at journalism and writers organizations, film festivals, museums, Turner Broadcasting, on cruise ships, at retirement communities, and even at health spas. 20 Lessons Learned From Interviewing the Famous & the Infamous When the National Scholastic Press Association asked if I would deliver a keynote address in 2010, I asked them what they would like me to talk about. I was also asked by Three Rivers Press, a division of Random House, to write a book about interviewing, which I did. They said, Why not talk about what you’ve learned as an interviewer? So I put together 20 examples of what I learned from interviewing people like Marlon Brando, Mae West, Norman Mailer, Barbra Streisand, Saul Bellow, Luciano Pavarotti, and Dolly Parton. Article date: September 2014 Domperidone is a dopamine antagonist with antiemetic properties. It should no longer be sold to anyone without a prescription. It is associated with a small increased risk of serious cardiac side effects (eg, QTc prolongation, torsade de pointes, serious ventricular arrhythmia, and sudden cardiac death). Therefore people need to have a medical assessment before taking domperidone to determine if it is suitable for them.

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