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    It is generally recognized in antipsychiatry circles that antidepressant drugs induce manic or hypomanic episodes in some of the individuals who take them. Such pathological shifts of mood and behavior may represent adverse drug actions or a manifestation of undiagnosed bipolar disorder.” The authors go on to state that they had reviewed available research on two topics: a) antidepressant-associated mood switching; b) changes of diagnosis from unipolar depression to bipolar disorder. Psychiatry’s usual response to this is to assert that the individual must have had an underlying latent bipolar disorder that has “emerged” in response to the improvement in mood. They identified 51 studies involving nearly 100,000 individuals who had been diagnosed with major depressive disorder (MDD) a history of mania or hypomania, and who had been treated with an antidepressant. to mania or hypomania) occurred in 8.2% of participants within an average of 2.4 years of antidepressant use, or per year. The problem with such a notion is that it is fundamentally unverifiable. (The rate of mood switching was 4.3 times greater among juveniles than among adults.) The authors also reviewed 12 other studies in which individuals who were initially considered to have unipolar depression (MDD), were assigned a new diagnosis of bipolar disorder because of the occurrence of spontaneous (i.e. These switches occurred in 3.3% of the individuals studied within 5.4 years, i.e. So, manic or hypomanic episodes were 5.6 (3.4 ÷ 0.6) times more likely per year for people diagnosed with MDD who were taking antidepressants than for people with the same diagnosis who were taking these drugs. Psychiatry defines “bipolar disorder” by the presence of certain behaviors and feelings. The authors’ comments on this difference in the Psychiatric Times article are interesting: “A particularly intriguing finding was the large apparent excess of antidepressant-associated switching over reported spontaneous diagnostic changes to bipolar disorder. If a person meets these criteria, he/she is said to bipolar disorder. What psychiatry is doing here is applying their spurious explanation the individual showed any signs of mania, he must have had bipolar disorder because he became manic at a later date. This raises questions about the diagnostic, prognostic, and therapeutic implications of antidepressant-associated reactions.” “If the relatively low rates of new bipolar diagnoses are not due to under-reporting, their marked difference from rates of antidepressant-associated mood switching leaves open the possibility that direct pharmacological, mood-elevating actions of antidepressants may be involved in mood switching, in addition to hypothesized “uncovering” or perhaps even “causing” of bipolar disorder. What immediately needs to be noted is that bipolar disorder, in common with psychiatry’s other “disorders” has no explanatory value. But nobody could ever have verified that hypothesis, because the occurrence of a manic or hypomanic episode is the primary criterion for such a “diagnosis”. Of particular concern is that these ambiguous possibilities leave specifically uncertain the potential value of long-term treatment with antimanic or putative mood-stabilizing agents.” In the Journal of Affective Disorders article, they also state: “An important, unresolved question is of the significance of AD-associated mood-switching. To illustrate this, consider the following hypothetical conversation. Psychiatrist: Because he behaves in these extreme ways. Why did my son become manic after starting on antidepressant drugs? Although the “latent bipolar disorder” is psychiatry’s usual explanation for these episodes, one occasionally encounters acknowledgement that the antidepressant was the primary causative factor, and in practice, the two conflicting theories exist side by side. Two plausible possibilities are: [a] responses reflecting the presence of BPD, or [b] a direct pharmacological effect of mood-elevating treatments that may be transient, relatively rapidly reversible, and not followed by a change in diagnosis…The several-fold higher proportion of patients with mood-switches among unipolar MDD patients than the rate of later re-diagnoses of BPD is consistent with the possibility that some AD-associated mood-switches may represent pharmacologic reactions (AD-induced mania). Antidepressants Linked to Increased Mania Risk - Medscape Sertraline made me manic has anyone else had this. Switching” of Mood From Depression to Mania With.
     
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